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Glossary

Entourage Effect

The entourage effect is a term used to describe the synergistic relationship between cannabinoids, terpenes, and other plant compounds found in cannabis. This theory suggests that all of these components work in harmony to enhance the overall effects of medical cannabis, rather than each one working in isolation.

The entourage effect is a widely accepted theory stating that the cannabinoids, terpenes, and other therapeutically beneficial chemicals produced by the Cannabis sativa L. family of plants all work synergistically in order to achieve the entourage effect, which is why full spectrum products are recommended when aiming for this outcome. 

 

Is the entourage effect scientifically proven?

 

No, but there is significant research and anecdotal evidence to support its existence. The entourage effect was first proposed by renowned cannabinoid researcher Dr. Ethan Russo in 1998. In his study, he found that the combination of cannabinoids and terpenes together had a greater therapeutic effect than each compound on its own. 

 

Is there research currently underway looking into the entourage effect?

 

Yes, there is ongoing research to further understand the entourage effect and its potential benefits. In the coming months, we can expect to see more studies published on the topic as the legalisation and research of cannabis continues to grow.

 

What cannabis derived medications offer the entourage effect?

 

Only options that include both cannabinoids and terpenes can produce the entourage effect. This means that whole plant extracts or products that contain a combination of different cannabinoids and terpenes, such as full-spectrum CBD oil, are more likely to offer this effect. Broad spectrum products, which contain all cannabinoids except for THC, may also offer some entourage effect benefits. 

To find out if you are eligible for medical cannabis treatment in the UK, check out our fast and free medical cannabis eligibility checker.

If you would like to learn more about medical cannabis in the UK, Releaf is here to help. In addition to this medical cannabis glossary, we have an extensive blog and education hub to explore, both filled with resources that UK medical cannabis patients, prescribers, and educators have been asking for.